Wednesday, December 7, 2011

New Sugar Molecule Compound Combo Primes Cancer Cells For Early Death in Multiple Cancers Paralleling A Well Known Fictional Story From the Movie 'The Medicine Man'



""Researchers at the University of California, San Diego School of Medicine and Kyushu University Medical School say a novel combination of a specific sugar molecule with a pair of cell-killing drugs prompts a wide variety of cancer cell types to kill themselves, a process called apoptosis or programmed cell death.

The findings are reported online in the journal Cancer Research.

“The goal of targeted therapy is to stop the growth of cancerous cells while doing little or no harm to healthy tissue,” said Guy Perkins, PhD, associate project scientist at the Center for Research in Biological Systems at UC San Diego. “Cancer researchers are always looking for new therapies to target a variety of cancers and kill tumor cells in various stages of development.”

Unfortunately, added co-author Ryuji Yamaguchi, PhD, senior researcher at Kyushu University Medical School in Fukuoka, Japan, “even the best new drugs seem to be limited to specific cancer types and too often tumor cells develop resistance to these drugs, leading to eventual treatment failure.”



The new two-part therapy described by Perkins and Yamaguchi focuses on depriving cancer cells of their fundamental need for sugar to fuel growth and multiplication. The first component is a modified glucose or sugar molecule called 2-deoxyglucose (2-DG). Although readily taken in by sugar-hungry cancer cells, it cannot be broken down to produce energy. Instead, it hampers cancer cell growth and primes the cells for early death by opening access to an internal protein that can trigger apoptosis.""

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""“We are now trying to initiate a clinical trial for the combination,” said Yamaguchi. “Since both 2-DG and ABT-263 (Navitoclax) are already in Phase II clinical trials (for other treatments), we know something about the safety of these agents. Once we take precautionary measures, the 2-DG-ABT combination therapy may prove an effective alternative to some existing cancer therapies. We may have found a simple, partial solution to a very complex disease.” ""



 In Depth Details of the Process To Treat These Mutated Cells Can Be Found Here:
http://health.ucsd.edu/news/2011/Pages/11-16-cancer-drug-combo.aspx
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